For healthcare professionals

Image of a box of Tiopex eye drops

SPC Patient Information

Introducing Tiopex®

Preservative free badge.
  • Non-infer­ior IOP control compared to 0.5% aqueous timolol drops
  • Tiopex contains timolol maleate 1 mg/g in a preservative-free, single-dose eye gel formulation
  • Timolol maleate is a non-cardioselective beta-blocker, with partial agonist potential and a non-significant membrane stabilising effect1
  • Timolol maleate reduces intraocular pressure (IOP)1

Tiopex is indicated for the reduction of elevated IOP in patients with ocular hypertension or chronic open angle glaucoma.1It is the only once-daily, preservative-free timolol gel.

Tiopex is lower strength than other timolol eye drops (0.1% compared to 0.25% or 0.5%) and is dosed once daily; however, it provides non-inferior IOP control compared to 0.5% aqueous timolol drops dosed twice daily over 24 hours2 and after 12 weeks.3,4

Patients switched from preserved 0.5% aqueous timolol twice daily to Tiopex have significantly lower adverse effects.4

Due to the lower strength and once-daily dose there is a 10-fold reduction in timolol administered and 90% less systemic absorption compared with timolol 0.5% twice daily.5

Tiopex features a ‘fluid gel’ vehicle (carbomer and polyvinyl alcohol) which enhances eye residency time and provides additional ocular comfort without significant blurring.6.7

image of a box of Tiopex eye drops, the blister pack inside and two unit doses

Key Features

  • More convenient dosing than aqueous timolol formulations (once vs twice daily) with non-inferior IOP control1,2
  • Longer residency on ocular surface than aqueous timolol, with improved ocular comfort6,7
  • Less systemic absorption than aqueous timolol at doses used5
  • Preservative free

How to use

Adults: The recommended dosage regimen is 1 drop of TIOPEX 1 mg/g in the affected eye(s), once a day, in the morning.

Children and adolescents: There is no experience in children and adolescents. This eye gel is therefore not recommended in such patients.

Keep the single-dose containers in the sachet and the outer carton in order to protect from light.

After opening of the sachet, use the single-dose containers within 1 month.

After opening of the single-dose container, use immediately and discard after use.

Pack contents

10 single-dose containers (PEBD) containing 0.4 g of gel are packed in each sachet (paper/aluminium).

Each box contains 3 sachets.

Pricing

Prescription only medicine.

NHS Price: £7.49 for a pack of 30 single dose containers

PIP code: 367-7069

References

  1. Tiopex Summary of Product Characteristics.
  2. Mayer H et al. Ophthalmologica 1996;210: 101-3.
  3. Rouland JF et al. Ophthalmologica 2002;216(6):449-54.
  4. Lester, M. et al. J. Ocular Pharm and Thearpeutics 2014; vol. 30, No. 6: 476-481.
  5. Uusitalo H et al. Acta Ophthalmol Scand 2005;83(6):723-8.
  6. Shedden, AH. Chibret. Int J Ophthalmo. 1994; 10: 32-6.
  7. Pouliquen, PJ. Fr. Ophtalmol 1999; 22(8): 903-13.

Page last updated: 4th October 2024

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